Parthenolide: Nature’s Potent Sesquiterpene Lactone

1. Molecular Identity

• Chemical Name: (1aR,4E,7aS,10aS,10bS)-1a,5-dimethyl-8-methylene-2,3,6,7,7a,8,10a,10b-octahydrooxireno[2′,3′:9,10]cyclodeca[1,2-b]furan-9(1aH)-one
• CAS Number: 20554-84-1
• Source: Primarily isolated from feverfew (Tanacetum parthenium) and other plants in the Asteraceae family

2. Biochemical Significance

Parthenolide is a sesquiterpene lactone with a unique α-methylene-γ-lactone ring structure. This molecular configuration contributes to its diverse biological activities, making it a compound of significant interest in natural product research and potential therapeutic applications.

3. Key Therapeutic Properties

• Anti-inflammatory: Demonstrates potent inhibition of NF-κB and other inflammatory pathways
• Anticancer: Shows promise in targeting cancer stem cells and inducing apoptosis
• Antimigraine: Exhibits potential in preventing and treating migraines
• Immunomodulatory: Modulates various aspects of immune response

4. Potential Applications

• Cancer research and drug development
• Inflammatory disorder studies and treatments
• Migraine prevention and management
• Immunological research and therapy development

5. Current Research Focus

Ongoing studies are investigating Parthenolide’s effects on:

• Various cancer types, particularly leukemia and solid tumors
• Inflammatory signaling pathways in chronic diseases
• Neuroinflammation and neuroprotection
• Autoimmune disorders and immunomodulation

6. Formulation Challenges and Innovations

Researchers are actively working on:

• Enhancing bioavailability through novel delivery systems
• Developing targeted formulations for specific tissues
• Creating stable, long-lasting preparations

7. Regulatory Considerations

As a naturally derived compound, Parthenolide’s (CAS 20554-84-1) regulatory status is evolving. Its use in specific therapeutic applications would require comprehensive safety and efficacy evaluations to meet regulatory standards.

8. Future Directions

The scientific community anticipates:

• Advanced clinical trials for cancer and inflammatory disorders
• Development of semi-synthetic derivatives with enhanced properties
• Exploration of synergistic effects with other natural compounds

9. Collaborative Opportunities

We invite researchers, pharmaceutical companies, and academic institutions to explore the therapeutic potential of Parthenolide. For inquiries, collaborations, or to discuss how Parthenolide can benefit your research or product development, please contact us at sales@nstchemicals.com.

Join us in unlocking the full potential of Parthenolide – a powerful sesquiterpene lactone at the forefront of natural product research and innovative therapeutic strategies.